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Article

Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion.

Biochimica et biophysica acta. Molecular cell research - 1 Apr 2017

Yin Huilong, Zheng Lu, Liu Weixiao, Zhang Dachuan, Li Wei, Yuan Li

Abstract excerpt

Centrosome cohesion, mostly regarded as a proteinaceous linker between parental centrioles, ensures the interphase centrosome(s) to function as a single microtubule-organizing center. Maintenance of centrosome cohesion counts on a number of centrosomal linker proteins because depletion of any of those leads to premature centrosome separation in interphase, termed centrosome splitting. However, the underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28089774
DOI: 10.1016/j.bbamcr.2017.01.007

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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