Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Opposing roles of TGFβ and BMP signaling in prostate cancer development.

Genes & development - 1 Dec 2017

Lu Xin, Jin Eun-Jung, Cheng Xi, Feng Shan, Shang Xiaoying, Deng Pingna, Jiang Shan, Chang Qing, Rahmy Sharif, Chaudhary Seema, Lu Xuemin, Zhao Ren, Wang Y Alan, DePinho Ronald A

Abstract excerpt

SMAD4 constrains progression of Pten-null prostate cancer and serves as a common downstream node of transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) pathways. Here, we dissected the roles of TGFβ receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate cancer model. These studies demonstrated that the molecular actions of TGFBR2 result in both SMAD4-dependent constraint...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein Receptors, Type II
Share to Bone Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kaplan-Meier Estimate

Share to Prostatic Neoplasms

Share to PTEN Phosphohydrolase

Share to Receptor, Transforming Growth Factor-beta Type II

Share to Receptors, Transforming Growth Factor beta

Share to Smad4 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 29352019
DOI: 10.1101/gad.307116.117
PMCID: PMC5795781

Genes

SMAD4
BMPR2
TGFBR2
BMP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Opposing roles of TGFβ and BMP signaling in prostate cancer development.PMID 29352019Read ↗

TGFβ signaling limits lineage plasticity in prostate cancer.Semantic proximity Read ↗

Deregulation of Negative Controls on TGF-β1 Signaling in Tumor ProgressionSemantic proximity Read ↗

Smad4-mediated TGF-β signaling in tumorigenesisSemantic proximity Read ↗

The TGF-β, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancerSemantic proximity Read ↗

The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to BoneSemantic proximity Read ↗

Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1Semantic proximity Read ↗

Androgenic Control of Transforming Growth Factor-β Signaling in Prostate Epithelial Cells through Transcriptional Suppression of Transforming Growth Factor-β Receptor IISemantic proximity Read ↗

TGFBR3 loss and consequences in prostate cancerSemantic proximity Read ↗

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathwaysSemantic proximity Read ↗

TGF‐β receptor‐mediated signalling through Smad2, Smad3 and Smad4Semantic proximity Read ↗

Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signalingSemantic proximity Read ↗

TGF-β Signaling in Mammary Gland Development and TumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.