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Article

<i>Pten</i> deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation

23 Jan 2006

Abstract excerpt

PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a potent tumor suppressor gene frequently mutated in human prostate cancers. Deletion of Pten in a murine model of prostate cancer recapitulates the disease progression seen in humans. Using defined cell lineage markers, we demonstrate that PTEN negatively regulates p63-positive prostatic basal cell proliferation without blocking differentiation....

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PMID: 16432235
DOI: 10.1073/pnas.0510652103

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