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Article

Prostate cancer induced by loss of Apc is restrained by TGFβ signaling.

PloS one - 1 Jan 2014

Bjerke Glen A, Pietrzak Karolina, Melhuish Tiffany A, Frierson Henry F, Paschal Bryce M, Wotton David

Abstract excerpt

Recent work with mouse models of prostate cancer (CaP) has shown that inactivation of TGFβ signaling in prostate epithelium can cooperate with deletion of the Pten tumor suppressor to drive locally aggressive cancer and metastatic disease. Here, we show that inactivating the TGFβ pathway by deleting the gene encoding the TGFβ type II receptor (Tgfbr2) in combination with a deletion of the Apc tumor suppressor...

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Source

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Identifiers

PMID: 24651496
DOI: 10.1371/journal.pone.0092800
PMCID: PMC3961420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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