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Article

Mannan-induced Nos2 in macrophages enhances IL-17-driven psoriatic arthritis by innate lymphocytes.

Science advances - 1 May 2018

Zhong Jianghong, Scholz Tatjana, Yau Anthony C Y, Guerard Simon, Hüffmeier Ulrike, Burkhardt Harald, Holmdahl Rikard

Abstract excerpt

Previous identification of the inducible nitric oxide synthase (NOS2) gene as a risk allele for psoriasis (Ps) and psoriatic arthritis (PsA) suggests a possible pathogenic role of nitric oxide (NO). Using a mouse model of mannan-induced Ps and PsA (MIP), where macrophages play a regulatory role by releasing reactive oxygen species (ROS), we found that NO was detectable before disease onset in mice, independent of...

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Source

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Identifiers

PMID: 29774240
DOI: 10.1126/sciadv.aas9864
PMCID: PMC5955621

Genes

MIP
NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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