Article

Targeting dendritic cell-specific TNFR2 improves skin and joint inflammation by inhibiting IL-12/ IFN-γ pathways in a mouse model of psoriatic arthritis

2024-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Psoriasis (PsO) and Psoriatic arthritis (PsA) are immune-mediated inflammatory diseases affecting the skin and joints. Approximately, 30% of patients with PsO develop PsA over time with both conditions being associated with elevated tumor necrosis factor-alpha (TNF-α) expression. TNF-α mediates its effect through two membrane receptors, TNFR1 and TNFR2. While current TNF-α-neutralizing agents, t...

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Literature Corpus work: 53a0fe7b-6cf9-55b5-87a1-1abbf4078bfc
DOI: 10.1101/2024.06.20.598545

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