Article

Rare coding variants in <i>NOX4</i> link high superoxide levels to psoriatic arthritis mutilans

2023-06-07

Abstract excerpt

<h4>Summary</h4> Psoriatic arthritis mutilans (PAM) is the rarest and most severe form of psoriatic arthritis. PAM is characterized by erosions of the small joints of hands and feet and osteolysis leading to joint disruption. Despite its severity, the underlying mechanisms are unknown, and no candidate susceptibility genes have hitherto been identified. We aimed to investigate the genetic basis of PAM. We perform...

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Literature Corpus work: 43a1138b-a2fd-5f7f-892c-19e8c4fe4e45
DOI: 10.1101/2023.06.06.543425

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