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Article

NOS2-derived low levels of NO drive psoriasis pathogenesis

26 Jun 2024

Abstract excerpt

Psoriasis is an IL-23/Th17-mediated skin disorder with a strong genetic predisposition. The impact of its susceptibility gene nitric oxide synthase 2 (NOS2) remains unknown. Here, we demonstrate strong NOS2 mRNA expression in psoriatic epidermis, an effect that is IL-17 dependent. However, its complete translation to protein is prevented by the IL-17-induced miR-31 implying marginally upregulated NO levels in...

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PMID: 38926337
DOI: 10.1038/s41419-024-06842-z

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