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Article

The P387 thrombospondin-4 variant promotes accumulation of macrophages in atherosclerotic lesions.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2020

Muppala Santoshi, Rahman Mohammed Tanjimur, Krukovets Irene, Verbovetskiy Dmitriy, Pluskota Elzbieta, Fleischman Aaron, Vince D Geoffrey, Plow Edward F, Stenina-Adognravi Olga

Abstract excerpt

Thrombospondin-4 (TSP4) is a pro-angiogenic protein that has been implicated in tissue remodeling and local vascular inflammation. TSP4 and, in particular, its SNP variant, P387 TSP4, have been associated with cardiovascular disease. Macrophages are central to initiation and resolution of inflammation and development of atherosclerotic lesions, but the effects of the P387 TSP4 on macrophages remain essentially...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32686880
DOI: 10.1096/fj.201901434RRRR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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