Article

The P387 Thrombospondin-4 Variant Promotes Accumulation of Macrophages in Atherosclerotic Lesions

2019-06-11

Abstract excerpt

<h4>Aims</h4> Thrombopspondin-4 (TSP4) is a pro-angiogenic protein that has been implicated in tissue remodeling and local vascular inflammation. TSP4 and, in particular, its SNP variant, P387 TSP4, have been associated with cardiovascular disease. Macrophages are central to initiation and resolution of inflammation and development of atherosclerotic lesions, but the effects of the P387 TSP4 on macrophages remain...

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Literature Corpus work: fd7c6135-aa85-5e83-8566-45cc2df447e5
DOI: 10.1101/666602

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