Structure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of <i>Legionella pneumophila</i>

Abstract excerpt

Prokaryotic pathogens have developed specialized mechanisms for efficient uptake of ferrous iron (Fe(2+)) from the host. In Legionella pneumophila, the causative agent of Legionnaires' disease, the transmembrane GTPase FeoB plays a key role in Fe(2+) acquisition and virulence. FeoB consists of a membrane-embedded core and an N-terminal, cytosolic region (NFeoB). Here, we report the crystal structure of NFeoB from...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Legionella and Acanthamoeba research
• Share to Neonatal Health and Biochemistry
• Share to Trace Elements in Health