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Article

Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA.

Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2010

Zhu Yongqun, Hu Liyan, Zhou Yan, Yao Qing, Liu Liping, Shao Feng

Abstract excerpt

Bacterial pathogens deliver effector proteins with diverse biochemical activities into host cells, thereby modulating various host functions. Legionella pneumophila hijacks host vesicle trafficking to avoid phagosome-lysosome fusion, a mechanism that is dependent on the Legionella Dot/Icm type IV secretion system. SidM/DrrA, a Legionella type IV effector, is important for the interactions of Legionella-containing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20176951
DOI: 10.1073/pnas.0914231107
PMCID: PMC2842064

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Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA.PMID 20176951Read ↗

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