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Structural insights into substrate recognition by the type VII secretion system

23 Nov 2019

Abstract excerpt

Abstract Type VII secretion systems (T7SSs) are found in many disease related bacteria includingMycobacterium tuberculosis(Mtb). ESX-1 [early secreted antigen 6 kilodaltons (ESAT-6) system 1] is one of the five subtypes (ESX-1~5) of T7SSs inMtb, where it delivers virulence factors into host macrophages during infection. However, little is known about the molecular details as to how this occurs. Here, we provide...

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PMID: 31758528
DOI: 10.1007/s13238-019-00671-z

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