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Article

A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer's Disease.

Mediators of inflammation - 1 Jan 2018

Durmanova Vladimira, Parnicka Zuzana, Javor Juraj, Minarik Gabriel, Vrazda Lubomir, Vaseckova Barbora, Gmitterova Karin, Kralova Maria, Pecenak Jan, Filipcik Peter, Shawkatova Ivana

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent cause of dementia in elderly people worldwide. Many studies support the hypothesis that the inflammation of the CNS contributes to the neurodegeneration and disease progression. The integrin molecule α4β1, also known as very late antigen 4 (VLA-4), belongs to adhesion molecules that activate the inflammatory process through the migration of immune cells into the CNS....

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Source

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Identifiers

PMID: 29769839
DOI: 10.1155/2018/7623823
PMCID: PMC5892238

Genes

ITGA4
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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