Article
Association of CD33 rs3865444:C˃A polymorphism with a reduced risk of late-onset Alzheimer's disease in Slovaks is limited to subjects carrying the APOE ε4 allele.
International journal of immunogenetics - 1 Oct 2020
Javor Juraj, Ďurmanová Vladimíra, Párnická Zuzana, Minárik Gabriel, Králová Mária, Pečeňák Ján, Vašečková Barbora, Režnáková Veronika, Šutovský Stanislav, Gmitterová Karin, Hromádka Tomáš, Peterajová Ľubica, Shawkatová Ivana
Abstract excerpt
CD33 rs3865444:C>A single nucleotide polymorphism (SNP) has been previously associated with the risk of late-onset Alzheimer's disease (LOAD); however, the results have been inconsistent across different populations. CD33 is a transmembrane receptor that plays an important role in AD pathogenesis by inhibiting amyloid β42 uptake by microglial cells. In this study, we aimed to validate the association between...
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