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Article

The role of VLA4 polymorphisms in multiple sclerosis: an association study.

Journal of neuroimmunology - 1 Sept 2007

Andreoli V, Cittadella R, Valentino P, Condino F, La Russa A, Liguori M, Manna I, Spadafora P, Nisticò R, Pirritano D, Clodomiro A, Quattrone A

Abstract excerpt

Lymphocyte and monocyte brain infiltration determines inflammation in multiple sclerosis. The trafficking of these cells into the CNS results from the VLA-4 binding with its ligand on brain endothelial cells. MS patients treated with an antibody against the alpha-4 subunit, which inhibits this interaction, prevents brain lesion development. We investigated the association between VLA-4 gene polymorphisms and MS...

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Source

Identifiers

PMID: 17609118
DOI: 10.1016/j.jneuroim.2007.06.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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