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CD39 Is Expressed on Functional Effector and Tissue-resident Memory CD8+ T Cells

8 Jul 2024

Abstract excerpt

The ecto-ATPase CD39 is expressed on exhausted CD8+ T cells in chronic viral infection and has been proposed as a marker of tumor-specific CD8+ T cells in cancer, but the role of CD39 in an effector and memory T cell response has not been clearly defined. We report that CD39 is expressed on Ag-specific CD8+ short-lived effector cells, while it's co-ectoenzyme, CD73, is found on memory precursor effector cells...

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PMID: 38975728
DOI: 10.4049/jimmunol.2400151

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