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Article

CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden.

Journal for immunotherapy of cancer - 1 Feb 2023

van den Bulk Jitske, van der Ploeg Manon, Ijsselsteijn Marieke E, Ruano Dina, van der Breggen Ruud, Duhen Rebekka, Peeters Koen C M J, Fariña-Sarasqueta Arantza, Verdegaal Els M E, van der Burg Sjoerd H, Duhen Thomas, de Miranda Noel F C C

Abstract excerpt

BACKGROUND: Expression of CD103 and CD39 has been found to pinpoint tumor-reactive CD8+ T cells in a variety of solid cancers. We aimed to investigate whether these markers specifically identify neoantigen-specific T cells in colorectal cancers (CRCs) with low mutation burden. EXPERIMENTAL DESIGN: Whole-exome and RNA sequencing of 11 mismatch repair-proficient (MMR-proficient) CRCs and corresponding healthy...

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Identifiers

PMID: 36792124
DOI: 10.1136/jitc-2022-005887
PMCID: PMC9933759

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