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Article

Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I.

The Journal of biological chemistry - 22 Jun 2018

Arshad Najla, Cresswell Peter

Abstract excerpt

Major histocompatibility complex-I-β2m dimers (MHC-I) bind peptides derived from intracellular proteins, enabling the immune system to distinguish between normal cells and those expressing pathogen-derived or mutant proteins. The peptides bind to MHC-I in the endoplasmic reticulum (ER), and this binding is facilitated by the peptide loading complex (PLC), which contains calreticulin (CRT). CRT associates with...

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Identifiers

PMID: 29769311
DOI: 10.1074/jbc.RA118.002836
PMCID: PMC6016473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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