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Article

Novel strategies targeting mutant calreticulin in essential thrombocythemia and myelofibrosis.

Blood - 19 Mar 2026

Salzman Gabriel S, Mullally Ann

Abstract excerpt

ABSTRACT: The discovery of calreticulin (CALR) mutations in patients with myeloproliferative neoplasms (MPNs) has paved the way for the elucidation of a unique disease mechanism that is particularly well suited to targeting by biologics. All MPN-associated pathogenic CALR mutations are characterized by a frameshift, resulting in translation of the same neoantigen peptide. This neoantigen directly activates the...

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Share to Calreticulin
Share to CALR gene
Share to Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Share to Primary Myelofibrosis

Share to Receptors, Thrombopoietin

Share to Thrombocythemia, Essential

Source

Open in PubMed Open full text

Identifiers

PMID: 40857671
DOI: 10.1182/blood.2025028642
PMCID: PMC13014093

Genes

CALR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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