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Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity

16 Jul 2025

Abstract excerpt

Effective immunotherapy relies on the presentation of tumor-derived neoantigens on the major histocompatibility complex class I (MHC-I) to activate CD8+ T cells. Deficiencies in this process are a key mechanism of immune evasion and resistance to checkpoint blockade. In this study, using an in vivo CRISPR-Cas9 screen, we unexpectedly found that inactivation of calreticulin (CALR), and other selected components of...

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PMID: 40833532
DOI: 10.1084/jem.20242360

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