Article
Production and Characterization of Peptide Antibodies to the C-Terminal of Frameshifted Calreticulin Associated with Myeloproliferative Diseases.
International journal of molecular sciences - 18 Jun 2022
Mughal Farah Perveen, Bergmann Ann Christina, Huynh Ha Uyen Buu, Jørgensen Sarah Hyllekvist, Mansha Inaam, Kesmez Meliha, Schürch Patrick Mark, Theocharides Alexandre Pierre André, Hansen Paul Robert, Friis Tina, Holmström Morten Orebo, Ciplys Evaldas, Slibinskas Rimantas, Højrup Peter, Houen Gunnar, Trier Nicole Hartwig
Abstract excerpt
Myeloproliferative Neoplasms (MPNs) constitute a group of rare blood cancers that are characterized by mutations in bone marrow stem cells leading to the overproduction of erythrocytes, leukocytes, and thrombocytes. Mutations in calreticulin (CRT) genes may initiate MPNs, causing a novel variable polybasic stretch terminating in a common C-terminal sequence in the frameshifted CRT (CRTfs) proteins. Peptide...
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