Article

Effects of Calreticulin Mutations on HLA Class I Expression in Myeloproliferative Neoplasms

2025-06-27

Abstract excerpt

Calreticulin (CRT) is important for human leukocyte antigen (HLA) class I assembly. Somatic mutations of the CRT gene ( CALR ) in hematopoietic lineage cells cause myeloproliferative neoplasms (MPNs). Typically, MPN patient cells have one copy each of the wild-type and mutant CALR allele. We find that heterozygous knock-in of a MPN CALR mutation into human cell lines maintains or slightly induces surface expres...

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Literature Corpus work: ae390602-b821-5a7d-9d56-3a92be94d571
DOI: 10.1101/2025.06.24.661416

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