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Article

Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis.

Oncoimmunology - 20 Jul 2020

Kepp Oliver, Liu Peng, Zhao Liwei, Plo Isabelle, Kroemer Guido

Abstract excerpt

Increased exposure of calreticulin (CALR) on malignant cells is associated with therapy-relevant adaptive immune responses and superior therapeutic outcome in solid tumors and haemato-oncological diseases, because surface-exposed CALR acts as an 'eat-me' signal facilitating the phagocytosis of stressed and dying cancer cells by immature dendritic cells, thus favoring antitumor immune responses. On the contrary,...

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Identifiers

PMID: 32923154
DOI: 10.1080/2162402X.2020.1792037
PMCID: PMC7458660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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