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Article

Brief introduction in phenotypic and genetic differences of C57BL/6 and BALB/c mice substrains.

Animal models and experimental medicine - 1 Sept 2025

Zhao Lan, Wei Jie, Yue Bingfei

Abstract excerpt

Experimental mice play a critical role in biomedical research. The phenotype and application of different substrains vary due to genetic differentiation and variation. To ensure validity and reliability of results, it is imperative to adhere to standardized experiments and controls. This paper objectively reviews the origin, differentiation, and phenotypic and genetic differences between the C57BL/6 and BALB/c...

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Identifiers

PMID: 40903912
DOI: 10.1002/ame2.70067
PMCID: PMC12531103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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