Article
Characterization of single nucleotide polymorphisms for a forward genetics approach using genetic crosses in C57BL/6 and BALB/c substrains of mice.
Experimental animals - 20 May 2022
Miura Ikuo, Kikkawa Yoshiaki, Yasuda Shumpei P, Shinogi Akiko, Usuda Daiki, Kumar Vivek, Takahashi Joseph S, Tamura Masaru, Masuya Hiroshi, Wakana Shigeharu
Abstract excerpt
Forward genetics is a powerful approach based on chromosomal mapping of phenotypes and has successfully led to the discovery of many mouse mutations in genes responsible for various phenotypes. Although crossing between genetically remote strains can produce F2 and backcross mice for chromosomal mapping, the phenotypes are often affected by background effects from the partner strains in genetic crosses. Genetic...
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