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Article

Lack of asmt1 or asmt2 Yields Different Phenotypes and Malformations in Larvae to Adult Zebrafish.

International journal of molecular sciences - 21 Apr 2025

Aranda-Martínez Paula, Fernández-Martínez José, Díaz-Casado María Elena, Ramírez-Casas Yolanda, Martín-Estebané María, López-Rodríguez Alba, Escames Germaine, Acuña-Castroviejo Darío

Abstract excerpt

Melatonin is an indolamine derived from tryptophan, which is highly conserved throughout evolution, including in zebrafish, where it controls important cellular processes, such as circadian rhythms, oxidative stress, inflammation, and mitochondrial homeostasis. These functions of melatonin and its synthesis route are quite similar to those in humans. One of the most important enzymes in melatonin synthesis is...

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Identifiers

PMID: 40332753
DOI: 10.3390/ijms26083912
PMCID: PMC12027777

Genes

ASMT

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