Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes.

Neuroscience - 9 Nov 2007

Vadasz C, Smiley J F, Figarsky K, Saito M, Toth R, Gyetvai B M, Oros M, Kovacs K K, Mohan P, Wang R

Abstract excerpt

The mesotelencephalic dopamine system shows substantial genetic variation which fundamentally affects normal and pathological behaviors related to motor function, motivation, and learning. Our earlier radioenzyme assay studies demonstrated significantly higher activity of tyrosine hydroxylase (TH), the first and rate limiting enzyme in the biosynthesis of catecholamine neurotransmitters, in the substantia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Count
Share to Cell Size
Share to Dopamine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mesencephalon

Share to Mice, Inbred BALB C

Share to Reference Standards

Share to Substantia Nigra

Share to Tyrosine 3-Monooxygenase

Source

Open in PubMed Open full text

Identifiers

PMID: 17920205
DOI: 10.1016/j.neuroscience.2007.06.049
PMCID: PMC2128036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes.PMID 17920205Read ↗

The midbrain dopaminergic system: anatomy and genetic variation in dopamine neuron number of inbred mouse strains.Semantic proximity Read ↗

Effects of the C.886C>T Mutation in the Mouse Tyrosine Hydroxylase Gene on Behavior and Dopamine System of the Brain.Semantic proximity Read ↗

Tyrosine Hydroxylase Deficiency Impairs TH Axonal Transport, Brain Function, and Neuronal Plasticity.Semantic proximity Read ↗

Analysis of the mesotelencephalic dopamine system by quantitative-trait locus introgression.Semantic proximity Read ↗

The C886T Mutation in the Th Gene Reduces the Activity of Tyrosine Hydroxylase in the Mouse Brain.Semantic proximity Read ↗

Quantitative trait locus mapping identifies <i>Col4a6</i> as a novel regulator of striatal dopamine level and axonal branching in miceSemantic proximity Read ↗

Strain- and age-dependent features of the nigro-striatal circuit in three common laboratory mouse strains, C57BL/6J, A/J, and DBA/2J - <i>Implications for Parkinson’s disease modeling</i>Semantic proximity Read ↗

Heritability, correlations and in silico mapping of locomotor behavior and neurochemistry in inbred strains of mice.Semantic proximity Read ↗

Tyrosine hydroxylase expression within Balb/C and C57black/6 mouse locus coeruleus. I. Topological organization and phenotypic plasticity of the enzyme-containing cell population.Semantic proximity Read ↗

MPTP susceptibility in the mouse: behavioral, neurochemical, and histological analysis of gender and strain differences.Semantic proximity Read ↗

Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice.Semantic proximity Read ↗

Normal nigrostriatal innervation but dopamine dysfunction in mice carrying hypomorphic tyrosine hydroxylase alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.