Article
Genetic variation of melatonin productivity in laboratory mice under domestication.
Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2010
Kasahara Takaoki, Abe Kuniya, Mekada Kazuyuki, Yoshiki Atsushi, Kato Tadafumi
Abstract excerpt
Melatonin is a pineal hormone produced at night; however, many strains of laboratory mice are deficient in melatonin. Strangely enough, the gene encoding HIOMT enzyme (also known as ASMT) that catalyzes the last step of melatonin synthesis is still unidentified in the house mouse (Mus musculus) despite the completion of the genome sequence. Here we report the identification of the mouse Hiomt gene, which was...
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