Article
Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity.
Cell reports - 15 May 2018
Hu Neng-Wei, Corbett Grant T, Moore Steven, Klyubin Igor, O'Malley Tiernan T, Walsh Dominic M, Livesey Frederick J, Rowan Michael J
Abstract excerpt
The early stages of Alzheimer's disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes of human iPSC-derived neuronal models of Alzheimer's disease. When introduced into the rat brain, secretomes from human neurons with either a presenilin-1 mutation, amyloid precursor protein...
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