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Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models

16 Apr 2014

Abstract excerpt

INTRODUCTION: Short-term neural stem cell (NSC) transplantation improves cognition in Alzheimer's disease (AD) transgenic mice by enhancing endogenous synaptic connectivity. However, this approach has no effect on the underlying beta-amyloid (Aβ) and neurofibrillary tangle pathology. Long term efficacy of cell based approaches may therefore require combinatorial approaches. METHODS: To begin to examine this...

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PMID: 25022790
DOI: 10.1186/scrt440

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