Article

Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region

2025-02-24

Abstract excerpt

Immunotherapies targeting extracellular tau share the premise that interrupting cell-to-cell spread of tau pathology in Alzheimer’s disease (AD) will slow dementia pathogenesis. How these interventions affect the actions of synaptotoxic, extracellular tau species that may help mediate cognitive impairment is relatively unknown. Here, we assayed synaptic plasticity disruption in anaesthetised live rats caused by in...

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Literature Corpus work: 06819174-79d4-53d3-b2a2-f9734b237cf8
DOI: 10.1101/2025.02.21.639417

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