Article

Targeting Clonal Mutations with Synthetic Microbes

2024-09-11

Abstract excerpt

Recently concluded, large-scale cancer genomics studies involving multiregion sequencing of primary tumors and paired metastases appear to indicate that most patients have one or more “clonal" mutations in their tumors. Clonal mutations are those that are present in all of a patient’s cancer cells. Clonally mutated proteins can potentially be targeted by inhibitors or E3 ligase glues, but developing ne...

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Literature Corpus work: 3673d215-bcd0-5da7-8fe3-e69909377d34
DOI: 10.20944/preprints202308.1536.v11

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