Article

Systemic tumor-targeting gene drive vectors proactively eliminate drug resistance in solid tumors

2025-10-05

Abstract excerpt

<h4>ABSTRACT</h4> While targeted therapies have revolutionized cancer treatment, drug resistance remains a major barrier to their curative potential. We recently demonstrated biological proof-of-concept for selection gene drive circuits, a technology that overwrites disease evolution to proactively eliminate resistance in vivo, but translation requires a delivery method compatible with disseminated metastatic dis...

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Literature Corpus work: bb3476e2-1de6-578e-afe6-619598a1946d
DOI: 10.1101/2025.10.04.680477

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