Article

In vivo correction of a TP53 hotspot mutation by base editing induces tumor regression.

2026-05-08

Abstract excerpt

<title>Abstract</title> <p>Despite rapid advances in precision genome editing, most clinical applications have focused on monogenic disorders. In contrast, therapeutic mutation correction in cancer has remained largely unexplored. Here, we demonstrate in vivo correction of the recurrent TP53-R273H hotspot mutation using adenine base editing in a peritoneal cancer mouse model. Liposome-mediated delivery of optimiz...

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Identifiers and source

Literature Corpus work: 03eb43e8-9976-58f8-ae1d-5ec8e685709a
DOI: 10.21203/rs.3.rs-9643229/v1

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