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Article

Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity

28 Feb 2018

Abstract excerpt

Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug target identification and drug discovery efforts. For any model to be clinically relevant, it needs to recapitulate the biology and cell heterogeneity of the primary tumor. We recently developed and described a conditional reprogramming (CR) cell technology that addresses...

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PMID: 29511269
DOI: 10.1038/s41598-018-22427-1

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