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Article

Fitness landscape of antibiotic tolerance in Pseudomonas aeruginosa biofilms.

PLoS pathogens - 1 Oct 2011

Amini Sasan, Hottes Alison K, Smith Lincoln E, Tavazoie Saeed

Abstract excerpt

Bacteria in biofilms have higher antibiotic tolerance than their planktonic counterparts. A major outstanding question is the degree to which the biofilm-specific cellular state and its constituent genetic determinants contribute to this hyper-tolerant phenotype. Here, we used genome-wide functional profiling of a complex, heterogeneous mutant population of Pseudomonas aeruginosa MPAO1 in biofilm and planktonic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22028649
DOI: 10.1371/journal.ppat.1002298
PMCID: PMC3197603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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