Article
The evolution of antibiotic susceptibility and resistance during the formation of Escherichia coli biofilms in the absence of antibiotics.
BMC evolutionary biology - 28 Jan 2013
Tyerman Jabus G, Ponciano José M, Joyce Paul, Forney Larry J, Harmon Luke J
Abstract excerpt
BACKGROUND: Explanations for bacterial biofilm persistence during antibiotic treatment typically depend on non-genetic mechanisms, and rarely consider the contribution of evolutionary processes. RESULTS: Using Escherichia coli biofilms, we demonstrate that heritable variation for broad-spectrum antibiotic resistance can arise and accumulate rapidly during biofilm development, even in the absence of antibiotic...
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