Article
A genome-wide view of the spectrum of spontaneous mutations in yeast.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2008
Lynch Michael, Sung Way, Morris Krystalynne, Coffey Nicole, Landry Christian R, Dopman Erik B, Dickinson W Joseph, Okamoto Kazufusa, Kulkarni Shilpa, Hartl Daniel L, Thomas W Kelley
Abstract excerpt
The mutation process ultimately defines the genetic features of all populations and, hence, has a bearing on a wide range of issues involving evolutionary genetics, inheritance, and genetic disorders, including the predisposition to cancer. Nevertheless, formidable technical barriers have constra...
Topics
- Base Sequence
- Cell Division
- Chromosomes, Fungal
- DNA, Mitochondrial
- Genome, Fungal
- Microsatellite Repeats
- Mutation
- Nucleotides
- Ploidies
- Saccharomyces cerevisiae