Article
A genome-wide view of the spectrum of spontaneous mutations in yeast.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2008
Lynch Michael, Sung Way, Morris Krystalynne, Coffey Nicole, Landry Christian R, Dopman Erik B, Dickinson W Joseph, Okamoto Kazufusa, Kulkarni Shilpa, Hartl Daniel L, Thomas W Kelley
Abstract excerpt
The mutation process ultimately defines the genetic features of all populations and, hence, has a bearing on a wide range of issues involving evolutionary genetics, inheritance, and genetic disorders, including the predisposition to cancer. Nevertheless, formidable technical barriers have constrained our understanding of the rate at which mutations arise and the molecular spectrum of their effects. Here, we...
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