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Article

The developmental origin of brain tumours: a cellular and molecular framework

14 May 2018

Abstract excerpt

The development of the nervous system relies on the coordinated regulation of stem cell self-renewal and differentiation. The discovery that brain tumours contain a subpopulation of cells with stem/progenitor characteristics that are capable of sustaining tumour growth has emphasized the importance of understanding the cellular dynamics and the molecular pathways regulating neural stem cell behaviour. By focusing...

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PMID: 29759978
DOI: 10.1242/dev.162693

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