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Cancer stem cells in gliomas: evolving concepts and therapeutic implications

27 Sept 2021

Abstract excerpt

PURPOSE OF REVIEW: Cancer stem cells (CSCs) have been implicated in the hierarchical heterogeneity and treatment resistance of hematologic and solid tumor malignancies, including gliomas, for several decades now but their therapeutic targeting has not been fully realized. Recent studies have uncovered deeper layers of CSC complexity, related to developmental origins, plasticity, cellular states, and interface...

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PMID: 34581301
DOI: 10.1097/wco.0000000000000994

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