Article
Both interaction surfaces within cohesin's hinge domain are essential for its stable chromosomal association.
Current biology : CB - 23 Feb 2010
Mishra Ajay, Hu Bin, Kurze Alexander, Beckouët Frédéric, Farcas Ana-Maria, Dixon Sarah E, Katou Yuki, Khalid Syma, Shirahige Katsuhiko, Nasmyth Kim
Abstract excerpt
BACKGROUND: The cohesin complex that mediates sister chromatid cohesion contains three core subunits: Smc1, Smc3, and Scc1. Heterotypic interactions between Smc1 and Smc3 dimerization domains create stable V-shaped Smc1/Smc3 heterodimers with a hinge at the center and nucleotide-binding domains (NBDs) at the ends of each arm. Interconnection of each NBD through their association with the N- and C-terminal domains...
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