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Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM 1 and CMTM 3 as priority targets

30 Apr 2015

Abstract excerpt

The novel CKLF-like Marvel Transmembrane Domain-containing gene family (CMTM) consists of 8 members (CMTM1-8). As little is known about the oncogenic impact of these genes, we aimed to systematically investigate the relevance of CMTMs to glioblastoma pathogenesis. We performed mRNA expression analyses and survival correlations in glioblastoma patients. Moreover, we analyzed the impact of RNAi-based silencing and...

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PMID: 25931111
DOI: 10.1002/gcc.22255

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