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Article

Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme.

Oncotarget - 29 Sept 2015

Kang Wonyoung, Kim Sung Heon, Cho Hee Jin, Jin Juyoun, Lee Jeongwu, Joo Kyeung Min, Nam Do-Hyun

Abstract excerpt

Glioblastoma multiforme (GBM) possesses florid angiogenesis. However, the anti-angiogenic agent, Bevacizumab, did not improve overall survival of GBM patients. For more durable anti-angiogenic treatment, we interrogated resistant mechanisms of GBM against Bevacizumab. Serial orthotopic transplantation of in vivo Bevacizumab-treated GBM cells provoked complete refractoriness to the anti-angiogenic treatment. These...

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Source

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Identifiers

PMID: 26336988
DOI: 10.18632/oncotarget.4835
PMCID: PMC4694986

Genes

TLN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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