Article
Association Between Genetic Variation in the SCN10A Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy.
International heart journal - 1 Jan 2015
Iio Chiharuko, Ogimoto Akiyoshi, Nagai Takayuki, Suzuki Jun, Inoue Katsuji, Nishimura Kazuhisa, Uetani Teruyoshi, Okayama Hideki, Okura Takafumi, Shigematsu Yuji, Tabara Yasuharu, Kohara Katsuhiko, Miki Tetsuro, Hamada Mareomi, Higaki Jitsuo
Abstract excerpt
Arrhythmias are associated with reduced quality of life and poor prognosis in patients with hypertrophic cardiomyopathy (HCM). Recent genome-wide association studies revealed that a nonsynonymous single nucleotide polymorphism, rs6795970, in the SCN10A gene was associated with the PR interval. We examined whether the PR prolonging allele (A allele) in the SCN10A gene may be associated with cardiac conduction...
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