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Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B

10 May 2018

Abstract excerpt

Toxic hijack of a cell signaling pathway The pathogen Clostridium difficile colonizes the human colon when the normal microbiota is disrupted, often after antibiotic treatment. It is a leading cause of hospital-acquired diarrhea, especially among elderly patients. Chen et al. describe a 2.5-Å-resolution crystal structure that shows how a major virulence factor in C. difficile , toxin B (TcdB), binds to the G...

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PMID: 29748286
DOI: 10.1126/science.aar1999

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