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Article

Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology.

PLoS pathogens - 1 Jan 2021

Pan Zhenrui, Zhang Yuanyuan, Luo Jianhua, Li Danyang, Zhou Yao, He Liuqing, Yang Qi, Dong Min, Tao Liang

Abstract excerpt

Clostridioides difficile toxin B (TcdB) is a key virulence factor that causes C. difficile associated diseases (CDAD) including diarrhea and pseudomembranous colitis. TcdB can be divided into multiple subtypes/variants based on their sequence variations, of which four (TcdB1-4) are dominant types found in major epidemic isolates. Here, we find that these variants are highly diverse in their receptor preference:...

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Identifiers

PMID: 33507919
DOI: 10.1371/journal.ppat.1009197
PMCID: PMC7842947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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