Article

Identification of the <i>C. sordellii</i> lethal toxin receptor elucidates principles of receptor specificity in clostridial toxins

2019-12-10

Abstract excerpt

Clostridium sordellii lethal toxin (TcsL) is responsible for an almost invariably lethal toxic shock syndrome associated with gynecological C. sordellii infections. Here, using CRISPR/Cas9 screening, we identify semaphorins SEMA6A and SEMA6B as the cellular receptors for TcsL and demonstrate that soluble extracellular SEMA6A can protect mice from TcsL-induced edema. A 3.3 Å cryo-EM structure shows that TcsL binds...

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Identifiers and source

Literature Corpus work: 23d85169-cb56-568d-a7ea-e147018466e0
DOI: 10.1101/871707

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