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Article

Defective mutations within the translocation domain of Clostridium difficile toxin B impair disease pathogenesis.

Pathogens and disease - 1 Feb 2016

Hamza Therwa, Zhang Zhifen, Melnyk Roman A, Feng Hanping

Abstract excerpt

The Clostridium difficile toxin B is one of the main virulence factors and plays an important role in the pathogenesis of C. difficile infection (CDI). We recently revealed crucial residues in the translocation domain of TcdB for the pore formation and toxin translocation. In this study, we investigated the effects of mutating a critical site involved in pore formation, Leu-1106, to residues that differ in size...

Topics

Animals
Bacterial Proteins
Bacterial Toxins
Clostridioides difficile
Clostridium Infections
DNA Mutational Analysis
Disease Models, Animal
Female
Mice
Mutation
Poisoning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pore Forming Cytotoxic Proteins

Protein Transport

Survival Analysis

Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 26507679
DOI: 10.1093/femspd/ftv098
PMCID: PMC4882082

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