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Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants

9 Nov 2022

Abstract excerpt

Toxin B (TcdB) is a major exotoxin responsible for diseases associated with Clostridioides difficile infection. Its sequence variations among clinical isolates may contribute to the difficulty in developing effective therapeutics. Here, we investigate receptor-binding specificity of major TcdB subtypes (TcdB1 to TcdB12). We find that representative members of subtypes 2, 4, 7, 10, 11, and 12 do not recognize the...

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Share to Clostridium difficile and Clostridium perfringens research
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PMID: 36351897
DOI: 10.1038/s41467-022-33964-9

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